Clinical-epidemiological profile of early sepsis in newborns A single-center observational study

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Fatima Ramirez Carillo
Cindy Lara Morales
Johanna Huacon Mazon
Stefania Stefania Loor Zambrano
Marilyn Urrutia Garces


Introduction: Early neonatal sepsis is a clinical syndrome characterized by signs and symptoms associated with systemic infection; it occurs in the first 72 hours after birth. This study aimed to determine the clinical-epidemiological profile of early neonatal sepsis in a neonatal intensive care unit of a regional reference center in Guayaquil, Ecuador.

Methods: The present observational study, carried out at the "Teodoro Maldonado Carbo" Hospital from January 2017 to December 2020, included neonates with early neonatal sepsis with a nonprobabilistic sample. The variables were age, gestational age, sex, route of infection, presence of urinary tract infections, weight, genopathies, Apgar at 1 minute, Silverman scale, clinical stages, capillary refill, urinary output, clinical and laboratory variables, haem culture, and causative organism. The analysis is univariate and descriptive with frequencies and percentages.

Results: A total of 278 patients with a mean gestational age of 33 weeks were included, and 59.4% were men. Maternal risk factors were UTI in pregnancy and transplacental infection. Among the factors associated with the newborn were low weight (56%) and prematurity (67%). The most frequent symptoms were euthermia and tachypnea (54%). In the laboratory profile, neutropenia predominated (49%), while the causative agents were Staphylococcus hominis (7%), Escherichia coli (4.3%), and Klebsiella pneumoniae (4%).

Conclusion: The direct relationship between the epidemiological characteristics and the clinical stages of neonatal sepsis was determined.


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How to Cite
Ramírez Carillo, F. ., Lara Morales, C. ., Huacón Mazon, J., Stefanía Loor Zambrano, S., & Urrutia Garcés, M. (2022). Clinical-epidemiological profile of early sepsis in newborns: A single-center observational study. Revista Ecuatoriana De Pediatría, 23(3), 192-200.
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Author Biography

Johanna Huacon Mazon, Neonatology Service, Hospital de Especialidades Teodoro Maldonado Carbo, Ecuadorian Institute of Social Se-curity, Guayaquil, Ecuador.

Physician from the University of Guayaquil (Guayaquil, 2012). Specialist in pediatrics from the Santiago de Guayaquil Catholic University (Guayaquil, 2016). Specialist in neonatology from the San Francisco De Quito University (Quito, 2019). Pediatric Neonatologist at the Teodoro Maldonado Carbo Specialty Hospital , IESS Guayaquil.

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