Secondary hyperparathyroidism is a risk factor associated with graft survival in pediatric patients with renal transplantation: a single-center study Original Research

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Luis Moreno Sánchez
Paúl Astudillo Neira
Freud Cáceres Aucatoma
Fernando Jimenez Jaramillo

Abstract

Introduction: Kidney transplantation in pediatrics is the treatment of choice for end-stage renal disease (ESRD) and has widely proven advantages over dialysis treatments. The aim of the present study was to determine the risk factors related to global and graft survival in a group of pediatric kidney transplant patients treated at a national referral hospital with observation of factors associated with secondary hyperparathyroidism.


Methods: The present observational, retrospective study was carried out in the Hospital Metropolitano de Quito, Ecuador, from January 1, 2010, to June 30, 2013. We studied mortality and graft survival, presence of hyperparathyroidism before transplantation, and demographic and clinical variables (compatibility). The Kaplan Meier method was used for analysis, and relative risks are presented.


Results: 33 patients aged 12 ± 3.8 years entered the study. There were cadaveric donors in 21 cases (63.6%) and living donors in 12 patients (36.4%). 18 were men (54.5%). The etiology of ESRD was indeterminate in 63.6%, nephropathies in 24.2%, and uropathies in 12.1%. there was cute rejection in 1 patient and late rejection in 10 patients. Variables with significance in graft survival were hyperparathyroidism (RR = 6.0 (95% CI = 1.078-45.902) P = 0.032), not receiving complete immunosuppression (RR = 14.5 (95% CI = 3.807-55.225) P <0.001), and the need for post-transplant dialysis in the first week and early biopsy (RR = 15 (95% CI = 3.9-57.2)).


Conclusions: This study demonstrated that secondary hyperparathyroidism is a negative risk factor for kidney graft survival in pediatric transplant patients.

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How to Cite
Moreno Sánchez, L., Astudillo Neira, P., Cáceres Aucatoma, F., & Jimenez Jaramillo, F. (2021). Secondary hyperparathyroidism is a risk factor associated with graft survival in pediatric patients with renal transplantation: a single-center study: Original Research. Ecuadorian Journal of Pediatrics, 22(2), Article 15:1-7. https://doi.org/10.52011/116
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Original Articles
Author Biographies

Luis Moreno Sánchez, Postgraduate Department in Pediatric Surgery, Universidad Internacional del Ecuador, Quito

Doctor in Medicine and Surgery from the Universidad Central del Ecuador (Ecuador 2005), Higher Diploma in Local Development and Health from the Universidad Técnica Particular de Loja (Ecuador 2006). Specialist in Pediatric Surgery from the Universidad Internacional del Ecuador (Ecuador 2016).

Paúl Astudillo Neira, Pediatric Surgery Service, Hospital Metropolitano de Quito

Doctor of Medicine and Surgery from the Universidad de Cuenca (Ecuador, 2005). Specialist in Pediatric Surgery from the Universidad de Barcelna (Spain 2011).

Freud Cáceres Aucatoma, Postgraduate Department in Pediatric Surgery, Universidad Internacional del Ecuador, Quito.

Doctor of Medicine and Surgery from the Pontificia Universidad Católica del Ecuador (Ecuador 2002). Specialist in Pediatric Surgery from the Universidad de Barcelona (Spain 2011), Master in training in Surgical techniques of Pediatric Surgery from the Universidad de Barcelona (Spain 2011), Doctor (PhD) in Child Physiopathology from the Universidad de Barcelona (Spain 2012).

Fernando Jimenez Jaramillo, Pediatric Surgery Service, Hospital Metropolitano de Quito

Doctor of Medicine and Surgery from the Universidad Central del Ecuador (Ecuador, 2003). Specialist in Nephrology from the Universidad Técnica Particular de Loja (Ecuador 2006).