Cannabidiol use in a pediatric patient with autism spectrum disorder and epilepsy Case Report

Abstract

Introduction: Autism spectrum disorder (ASDs) are made up of neuropsychiatric disorders characterized by difficulties in social interaction and communication associated with restrictive and stereotyped activities and interests. Conventional psychopharmacological medications are usually directed to the treatment of associated behaviors but do not treat the core deficits of ASD.

Clinical case: A 3-year-old boy was treated for delayed language acquisition and age-inappropriate behaviors compatible with manifestations of ASD. In addition, an electroencephalogram showed paroxysmal discharges coinciding with episodes of disconnection from the environment. The parents decided to use cannabidiol and to start a psychomotor, behavioral, and speech therapy intervention program.

Evolution: After one year of intervention and follow-up, there were significant advances in seizure control and improvement in empathic, adaptive, and relational skills. The child tolerates closed spaces better and follows orders and simple routines. The therapist indicates great progress, and the child has finished his first year of schooling with significant achievements. EEG study showed better conditions than previous results with better-structured baseline activity and decreased frontal epileptogenic activity.

Conclusion: This case report reinforces the idea that early therapeutic intervention and the use of cannabidiol as an add-on therapy may be able to aid in seizure control in epilepsy and decrease behavioral symptoms related to ASD. Further research is needed to elucidate the effectiveness of cannabidiol in ASD.